منابع مشابه
GPCR signalling in hypertension: role of GRKs.
Hypertension is a prevalent condition in the developed world and disease severity is directly correlated with additional cardiovascular complications. It is estimated that 30% of the adult population in the United States has hypertension, which is classified as a systolic blood pressure > or =140 mmHg and/or a diastolic blood pressure > or =90 mmHg. A prolonged increase in afterload ultimately ...
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The critical involvement of GPCRs (G-protein-coupled receptors) in nearly all physiological processes, and the presence of these receptors at the interface between the extracellular and the intracellular milieu, has positioned these receptors as pivotal therapeutic targets. Although a large number of drugs targeting GPCRs are currently available, significant efforts have been directed towards u...
متن کاملSpatial encoding of cyclic AMP signalling specificity by GPCR endocytosis
G protein-coupled receptors (GPCRs) are well known to signal via cyclic AMP (cAMP) production at the plasma membrane, but it is now clear that various GPCRs also signal after internalization. Apart from its temporal impact through prolonging the cellular response, we wondered whether the endosome-initiated signal encodes any discrete spatial information. Using the β2-adrenoceptor (β2-AR) as a m...
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The pHs of extracellular fluids (ECFs) in humans are consistently maintained at 7.35 to 7.45 in physiological conditions. Pathological changes, including infarction, tumourigenesis and inflammation, commonly result in decreases in the ECF pH in the affected tissues. In this study, we report that proliferation is promoted and apoptosis is inhibited by decreases in extracellular pH. Furthermore, ...
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Lineage decisions in development are thought to be primarily due to differential activation of transcription factors. However, cell position and subcellular organization of signalling also play a role. New studies of the Hippo pathway in the early mouse embryo show how.
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2013
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3577